Research
Grants Jointly Sponsored by the
NNPDF and CCNNPDF
Note: The project status shown below reflects only the Foundation's involvement. A number of the studies listed have been continued or expanded under the sponsorship of NIH and other organizations.
(To see a listing of the Fellowships jointly sponsored by the NNPDF and CCNNPDF, click here.)
(To see a listing of the Clinical Research and Services funded by the NNPDF, click here.)
| Item # | Date | Researcher | Project | Additional Information |
| 50 | 8/2011 - 7/2013 |
Charles Vite, D.V.M., Ph.D. School of Veterinary Medicine University of Pennsylvania - Philadelphia |
NPC Cat colony In progress |
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| 49 | 8/2009 | Jackson Laboratory Repository | Processing the NPD mouse model developed by Dr. Richard Pagano of the Mayo Clinic College of Medicine $2500 Jointly sponsored by NNPDF and CCNNPDF Completed |
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| 48 | 4/1/2008 - 3/31/2009 | Edward H. Schuchman, Ph.D. (Mount Sinai School of Medicine, New York,NY, USA) (1 Year) |
Construction & Characterization of New Mouse Models for Types A & B Niemann-Pick $46,593 Jointly sponsored by NNPDF and CCNNPDF Completed |
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| 47 | 3/1/2008 - 2/28/2010 | Frances M. Platt, Ph.D. & Emyr Lloyd-Evans, Ph.D. (University of Oxford, Oxford, UK) (2 years) |
Targeting sphingosine storage as a new therapeutic approach for Niemann-Pick type C $161,097 Jointly sponsored by NNPDF and CCNNPDF Completed |
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| 46 | 4/1/2007 - 3/31/2008 | Lysosomal Storage Disease Research Consortium (Multiple) (1 year) |
Additional contribution to Lysosomal Storage Disease
(LSD) Research Consortium for research into issues of common interest
to all LSD support groups (See also Grant # 40) $10,000 Jointly sponsored by NNPDF and CCNNPDF Completed |
More Details... |
| 45 | 3/1/2007 - 2/29/2008 | Frances M. Platt, Ph.D. (University of Oxford) (1 year) |
Evaluation of anti-inflammatory intervention (NSAIDS)
as an adjunctive therapy in Niemann-Pick Type C1 disease. $99,090 Jointly sponsored by NNPDF and CCNNPDF Completed |
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| 44 | 4/1/2006 - 3/31/2007 | Lysosomal Storage Disease Research Consortium (Multiple) (1 year) |
Additional contribution to LSD Research Consortium for
research into issues of common interest to all LSD support groups (See also Grant # 40) $10,000 Completed |
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| 43 | 9/1/2006 - 8/31/2007 | Maria D. Ledesma, Ph.D. (Catholic University of Leuven; Leuven; Belgium) (1 year) |
Analysis of Dendritic Spine Alterations in Niemann-Pick
Disease Type A Neurons $19,760 Bridge Funding Completed |
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| 42 | 6/1/2006 - 12/31/2007 | Kostantin Dobrenis, Ph.D. (Albert Einstein College of Medicine of Yeshiva University; Bronx, New York; USA) (18 months) |
Establishment of Central Nervous System Cell Lines from
NPC-1 Disease Mice for Pathogenic and Therapeutic Studies $80,240 Completed |
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| 41 | 5/1/2006 - 11/30/2006 | Frances M. Platt, Ph.D. (University of Oxford; Oxford, England; UK) (7 months) |
Therapeutic Monitoring of Glycolipid Storage Diseases
in the Clinic Using Cell Biological Assays and Proteomics $50,000 Bridge Funding Completed |
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| 40 | 4/1/2004 - 3/31/2006 | Lysosomal Storage Disease Research Consortium (Multiple) | Lysosomal Storage Disease Research Consortium Contribution
for NNPDF to Join Consortium $10,000 Completed |
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| 39 | 4/15/2005 - 4/14/2006 | Robert A. Maue, Ph.D. (Dartmouth Medical School; Hanover, New Hampshire; USA) (1 year) |
Maintenance of Colony of NPC1 mice with GFP-tagged Purkinje
neurons $6,000 Bridge Funding Completed |
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| 38 | 5/1/2005 - 4/30/2006 | Thomas J. Kelley, Ph.D. (Case Western Reserve University; Cleveland, Ohio; USA) (1 year) |
NOS2 regulation in NPC $55,000 Major funding provided by the Niemann-Pick Disease Group (UK). Completed |
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| 37 | 4/1/2005 - 4/1/2007 | Richard E. Pagano, Ph.D. and David L. Marks, Ph.D. (Mayo Clinic and Foundation; Rochester, Minnesota; USA) (2 years) |
Reduction of stored lipids in Niemann-Pick Type C mice
by rab protein expression $177,562 Completed |
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| 36 | 9/15/2004 - 9/14/2005 | Maria D. Ledesma, Ph.D. (Fundazione Cavalieri Ottolenghi; Turin, Italy) (1 year) |
Organization of Synapses in Niemann-Pick Disease Type
A $50,000 Completed |
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| 35 | 4/1/2004 - 3/31/2005 | Synthia Mellon, Ph.D. (University of California, San Franciso; San Francisco, California, USA) (1 year) |
SSRIs as a potential therapy for NP-C $50,000 Jointly funded with Dana's Angels Research Trust . Total project cost is: $97,769. Completed |
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| 34 | 3/1/2004 - 2/28/2005 | Stuart A. Lipton, M.D., Ph.D. (The Burnham Institute; La Jolla, California, USA) (1 year) |
NMDA receptor hypofunction in Niemann-Pick disease Type
A $50,000 Completed |
More Details... |
| 33 | 9/15/2003 - 9/14/2004 | Makoto Michikawa, M.D., Ph.D. (National Institute for Longevity Sciences; Aichi, Japan) (1 year) |
Cellular and Molecular Mechanisms Underlying Neurodegeneration
in Niemann- Pick Type C disease $50,000 Completed |
More Details... |
| 32 | 7/1/2003 - 8/31/2004 | Timothy M. Cox, MD, FRCP, FMedSci & Robin Henry
Lachmann, M.A., M.B., Bchir, Ph.D. (University of Cambridge; Cambridge, United Kingdom) (10 months) |
Therapeutic Gene Delivery to the Cerebellum in Niemann-Pick
Type C $40,000 (Transitional Funding - used for PostDoc) Completed |
More Details... |
| 31 | 8/15/2002 - 8/14/2003 | Maria D. Ledesma, Ph.D. (Fundazione Cavalieri Ottolenghi; Turin, Italy) (1 year) |
Niemann-Pick Disease Type A: Molecular Analysis of Neuronal
Membrane Maturation and Synapse Formation $50,000 Completed |
More Details... |
| 30 | 8/1/2002 - 7/31/2003 | Anita H. Corbett, Ph.D. (Emory University School of Medicine; Atlanta, Georgia, USA) (1 year) |
Functional Analysis of NPC1 $50,000 Completed |
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| 29 | 2/15/2002 - 2/14/2003 | Melanie Jean Dobson, Ph.D. (Dalhousie University; Halifax, Nova Scotia, Canada) (1 year) |
A Yeast System for Analysis of Sterol Trafficking Defects
in NPC $42,000 Completed |
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| 28 | 8/15/2001 - 8/14/2003 | Daniel S. Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA) (2 years) |
The Role of HE1 in Cholesterol Trafficking $154,147 Completed |
More Details... |
| 27 | 8/15/2001 - 8/14/2002 | Skadrite Krisans, Ph.D. (San Diego State University; San Diego, California, USA) (1 year) |
Role of Peroxisomal Cholesterol/Myelin Formation in
the CNS Pathology of the NPC Mouse $50,000 Completed |
|
| 26 | 2/1/2001 - 1/31/2002 | Anthony H. Futerman, Ph.D. (Weizmann Institute; Rehovot, Israel) (1 year) |
Neuronal Development & Death in Type A Niemann-Pick
Disease $50,000 Completed |
More Details... |
| 25 | 8/15/2000 - 8/14/2001 | Mary Anna Thrall; DVM (Colorado State University; Fort Collins, Colorado, USA) (1 year) |
Characterization of Feline Niemann-Pick Type C $40,216 Completed |
Faculty page |
| 24 | 9/1/2000 - 8/31/2001 | Yiannis A. Ioannou, Ph.D. (Mount Sinai School of Medicine; New York, New York, USA) (1 year) |
Functional Characterization of NPC1L1, a Human Homologue
of NPC1 $60,000 Completed |
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| 23 | 8/15/2000 - 8/14/2003 | Robert A. Maue, Ph.D. (Dartmouth College) (3 years) |
Analysis of Growth Factor Actions and Membrane Polarity
in Neurons from NP-C Mice $131,988 (No Cost Extension Received in August, 2002; Completion Date Changed to August, 2003) Completed |
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| 22 | April, 2000 | Daniel S. Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of the Niemann-Pick Type C2 Gene $125,752 Completed |
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| 21 | February, 2000 | Cynthia J. Forehand, Ph.D. (University of Vermont; Burlington, Vermont, USA) |
Glutamate Receptors and Neuronal Degeneration in Niemann-Pick
Type C Disease $27,107 Completed |
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| 20 | April, 2000 | Lisa D. Griffin, M.D., Ph.D. (University of California - San Francisco; San Francisco, California, USA) |
Altered Neurosteroidogenesis in Niemann-Pick Type C
Disease $40,000 (Extension of Grant # 16) Completed |
|
| 19 | February, 2000 | James Shayman, M.D. (University of Michigan; Ann Arbor, Michigan, USA) |
Treatment of Niemann-Pick Type C Disease with Potent
Inhibitors of Cerebroside Synthase $40,000 Completed |
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| 18 | August, 1999 | Leslie P. Henderson (Dartmouth College, Hanover, New Hampshire, USA) |
Analysis of NPC1 mRNA Expression in the Mouse Brain $14,592 (Extension of Grant # 10) Completed |
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| 17 | July, 1999 | Daniel Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of NPC2 Gene $110,000 Extended (See Grant # 22) |
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| 16 | June, 1999 | Lisa Griffin, M.D., Ph.D. (University of California - San Francisco; San Francisco, California, USA) |
The Role of Neurosteroids in the Development of Niemann-Pick
Type C $34,000 Completed |
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| 15 | June, 1999 | Frederick R. Maxfield, Ph.D. (Weill Medical College of Cornell University; New York, New York, USA) |
Intracellular Cholesterol Trafficking in Niemann-Pick
Type C Disease $15,000 Completed |
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| 14 | September, 1998 | Jerry Reagan, Ph.D. (Wake Forest University School of Medicine; Winston-Salem, North Carolina, USA) |
Acid Sphingomyelinase Regulates Cholesterol Egress from
Lysosomes by an Alternative Pathway $15,000 Completed |
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| 13 | April, 1998 | Daniel Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of NPC2 Gene $60,000 Extended (See Grant #17) |
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| 12 | February, 1998 | Jill Morris, Ph.D. (National Institutes of Health; Bethesda, Maryland, USA) |
Identification of Additional NPC1 Mutations $31,000 Completed |
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| 11 | March, 1998 | Ira Tabas, M.D., Ph.D. (Columbia University; New York, New York, USA) |
Phospholipid Metabolism and Cholesterol-Induced Cytotoxicity
in Niemann-Pick C Macrophages $15,000 Completed |
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| 10 | March, 1998 | Leslie P. Henderson, Ph.D. (Dartmouth College, Hanover, New Hampshire, USA) |
Analysis of NPC1 mRNA Expression in the Mouse Brain $14,742 Extended (See Grant # 18) |
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| 9 | March, 1997 | Marc Patterson, M.D. (Mayo Clinic; Rochester, Minnesota, USA) |
Lipid Trafficking in the Neurons of NPC Mice $11,000 Completed |
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| 8 | January, 1997 | Synthia Mellon, Ph.D. (University of California - San Francisco; San Francisco, California; USA) |
Potential Involvement of Neurosteroids in the Neurobiological
Dysfunctions of NP-C $30,044 Completed |
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| 7 | October, 1996 | Marc Patterson, M.D. (Mayo Clinic; Rochester, Minnesota, USA) |
Establish an International Registry (database) of NPC
Families $10,213 |
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| 6 | July, 1996 | G. S. Tint, Ph.D. (Veterans Adminstration Medical Center; East Orange, New Jersey, USA) |
Accumulation of Oxidized Cholesterol as a Possible Cause
of Pathologies Associated with Niemann-Pick Type C Disease $14,000 Completed |
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| 5 | June, 1996 | John R. Sargent, Ph.D. (University of Stirling; Stirling, Scotland, United Kingdom) |
Influence of Exogenous Fatty Acids on Levels of Cholesterol
in Cultured Skin Fibroblasts from NPC Patients $28,050 Completed |
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| 4 | January, 1996 | Wenda L. Greer, Ph.D. (Dalhousie University; Halifax, Nova Scotia, Canada) |
Identification of Niemann-Pick Type D Patients with
Arcadian Ancetsry as a Step Toward Isolation of the Defective Gene $12,357 Completed |
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| 3 | Nov, 1995 | Charles C. Schwartz, M.D. (Medical College of Virginia; Richmond, Virginia, USA) |
Quantitation of Cholesterol Transport and Tissue Cholesterol
Pool Sizes In Vivo Niemann-Pick Type C Disease $32,000 Completed |
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| 2 | April, 1994 | Laura Liscum, Ph.D. (Tufts University School of Medicine; Boston, Massachusetts, USA) |
Complementation Analyses of Niemann-Pick Type C Fibroblasts'
Cholesterol Transport in Defective CHO Cells $8,900 Completed |
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| 1 | 7/1/1993 - 6/30/1997 | Eugene Carstea, Ph.D. (National Institutes of Health; Bethesda, Maryland, USA) (5 years) |
Identify the Gene Responsible for Niemann-Pick Type
C Disease $160,000 Completed |
More Details... |
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